Platelets and Megakaryocytes: Volume 1: Functional Assays
(Methods in Molecular Biology, Volume 272)
Jonathan M. Gibbins (Editor), Martyn P. Mahaut-Smith (Editor)
Book Description
For both volumes:
A comprehensive collection of cutting-edge methods for the molecular and cellular
analysis of platelets and megakaryocytes. Volume 1 details basic and advanced
techniques for analyzing platelet and megakaryocyte function. The approaches presented for platelet analysis include aggregometry, secretion, arachidonic acid metabolism, procoagulent response, platelet adhesion under static and flow conditions, flow cytometry, and production of microparticles. The techniques for study of megakaryocyte function allow the measurement of specialized structures for platelet production, the appearance of platelet-specific surface receptors, and the increase in ploidy. Volume 2 offers techniques for studying many aspects of signaling in platelets and megakaryocytes, as well as state-of-the-art commentaries on our understanding of these cells. The methods include ligand-binding assays, the study of protein and lipid kinases and phosphatases, the analysis of lipid rafts, and the measurement of intracellular calcium levels. There are also techniques for study of electrophysiological events, nitric oxide signaling, venom proteins, and for the internalization of proteins into platelets through permeabilization. This volume also describes the application of molecular and post-genomic methods for the study of platelets and megakaryocytes. All protocols follow the successful Methods in Molecular Biology™ series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. The two volumes offer novice and experienced cell biologists, hematologists, and clinicians not only a benchmark survey of the field, but also a comprehensive library of proven techniques essential for productive research on platelets and megakaryocytes today.
(Methods in Molecular Biology, Volume 272)
Jonathan M. Gibbins (Editor), Martyn P. Mahaut-Smith (Editor)
Book Description
For both volumes:
A comprehensive collection of cutting-edge methods for the molecular and cellular
analysis of platelets and megakaryocytes. Volume 1 details basic and advanced
techniques for analyzing platelet and megakaryocyte function. The approaches presented for platelet analysis include aggregometry, secretion, arachidonic acid metabolism, procoagulent response, platelet adhesion under static and flow conditions, flow cytometry, and production of microparticles. The techniques for study of megakaryocyte function allow the measurement of specialized structures for platelet production, the appearance of platelet-specific surface receptors, and the increase in ploidy. Volume 2 offers techniques for studying many aspects of signaling in platelets and megakaryocytes, as well as state-of-the-art commentaries on our understanding of these cells. The methods include ligand-binding assays, the study of protein and lipid kinases and phosphatases, the analysis of lipid rafts, and the measurement of intracellular calcium levels. There are also techniques for study of electrophysiological events, nitric oxide signaling, venom proteins, and for the internalization of proteins into platelets through permeabilization. This volume also describes the application of molecular and post-genomic methods for the study of platelets and megakaryocytes. All protocols follow the successful Methods in Molecular Biology™ series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. The two volumes offer novice and experienced cell biologists, hematologists, and clinicians not only a benchmark survey of the field, but also a comprehensive library of proven techniques essential for productive research on platelets and megakaryocytes today.
| CODE |
| http://www.amazon.com/Platelets-Megakaryocytes-Functional-Methods-Molecular/dp/1588291014 |
Hardcover: 408 pages
Publisher: Humana Press; 1 edition (July 1, 2004)
Language: English
ISBN-10: 1588291014
ISBN-13: 978-1588291011
Price: $104.65
File Type: PDF
File Size: 15645 KB
Download:
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| http://rapidshare.com/files/31821834/272-Platelets_and_Megakaryocytes_Volume_1_MMolBio_.zip.html |
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